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Article

G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.

Journal of human hypertension - 1 May 2012

Rayner B, Ramesar R, Steyn K, Levitt N, Lombard C, Charlton K

Abstract excerpt

Dopamine via G-protein-coupled receptor kinase 4 (GRK-4) regulates sodium (Na) balance in the proximal tubule of the kidney. Single-nucleotide polymorphisms of GRK-4 have been linked to impaired natriuresis and salt-sensitive hypertension. The purpose of this report was to determine the effect of GRK-4 gene polymorphisms on the blood pressure (BP) responses to dietary intervention. Black subjects aged 50-75 years...

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Identifiers

PMID: 21544086
DOI: 10.1038/jhh.2011.33

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