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Article

A requirement of TolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli.

PloS one - 26 Apr 2011

Deininger Kari N W, Horikawa Akina, Kitko Ryan D, Tatsumi Ryoko, Rosner Judah L, Wachi Masaaki, Slonczewski Joan L

Abstract excerpt

BACKGROUND: The TolC outer membrane channel is a key component of several multidrug resistance (MDR) efflux pumps driven by H(+) transport in Escherichia coli. While tolC expression is under the regulation of the EvgA-Gad acid resistance regulon, the role of TolC in growth at low pH and extreme-acid survival is unknown. METHODS AND PRINCIPAL FINDINGS: TolC was required for extreme-acid survival (pH 2) of strain...

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Source

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Identifiers

PMID: 21541325
DOI: 10.1371/journal.pone.0018960
PMCID: PMC3082540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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