Article
Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria.
Biophysical journal - 4 May 2011
Acehan Devrim, Malhotra Ashim, Xu Yang, Ren Mindong, Stokes David L, Schlame Michael
Abstract excerpt
F(1)F(0) ATP synthase forms dimers that tend to assemble into large supramolecular structures. We show that the presence of cardiolipin is critical for the degree of oligomerization and the degree of order in these ATP synthase assemblies. This conclusion was drawn from the statistical analysis of cryoelectron tomograms of cristae vesicles isolated from Drosophila flight-muscle mitochondria, which are very rich...
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