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Article

Dynamin-related protein 1 is implicated in endoplasmic reticulum stress-induced pancreatic β-cell apoptosis.

International journal of molecular medicine - 1 Aug 2011

Peng Liang, Men Xiuli, Zhang Wenjian, Wang Haiyan, Xu Shiqing, Xu Mei, Xu Yaping, Yang Wenying, Lou Jinning

Abstract excerpt

Pancreatic β-cell dysfunction is a critical component in the pathogenesis of diabetes. Endoplasmic reticulum (ER) stress is one of the factors that induces pancreatic β-cell dysfunction, but the underlying mechanisms have not been well elucidated. In this study, we report that a mitochondrial fission modulator, dynamin-related protein 1 (DRP-1), plays an important role in ER stress-induced β-cell apoptosis....

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Identifiers

PMID: 21537829
DOI: 10.3892/ijmm.2011.684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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