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Article

Requirement of Podocalyxin in TGF-Beta Induced Epithelial Mesenchymal Transition

12 Apr 2011

Abstract excerpt

Epithelial mesenchymal transition (EMT) is characterized by the development of mesenchymal properties such as a fibroblast-like morphology with altered cytoskeletal organization and enhanced migratory potential. We report that the expression of podocalyxin (PODXL), a member of the CD34 family, is markedly increased during TGF-β induced EMT. PODXL is enriched on the leading edges of migrating A549 cells. Silencing...

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PMID: 21533279
DOI: 10.1371/journal.pone.0018715

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