Article
The Duchenne muscular dystrophy gene and cancer.
Cellular oncology (Dordrecht, Netherlands) - 1 Feb 2021
Jones Leanne, Naidoo Michael, Machado Lee R, Anthony Karen
Abstract excerpt
BACKGROUND: Mutation of the Duchenne muscular dystrophy (DMD) gene causes Duchenne and Becker muscular dystrophy, degenerative neuromuscular disorders that primarily affect voluntary muscles. However, increasing evidence implicates DMD in the development of all major cancer types. DMD is a large gene with 79 exons that codes for the essential muscle protein dystrophin. Alternative promotor usage drives the...
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