Article
The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study.
Journal of the American Academy of Dermatology - 1 Jul 2011
Fiorentino David, Chung Lorinda, Zwerner Jeff, Rosen Antony, Casciola-Rosen Livia
Abstract excerpt
BACKGROUND: Dermatomyositis (DM) is a multisystem autoimmune disease, in which serologic evidence of immune responses to disease-specific antigenic targets is found in approximately 50% to 70% of patients. Recently, melanoma differentiation-associated gene 5 (MDA5) has been identified as a DM-specific autoantigen that appears to be targeted in patients with DM and mild or absent muscle inflammation and with an...
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