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Article

Clinical phenotype and prognostic determinants of spontaneous pneumomediastinum in anti-MDA5 antibody-positive dermatomyositis.

Frontiers in immunology - 1 Jan 2026

Wang Xiaoying, Zhang Yusheng, Liu Lijun, Li Wei, Liu Xiaojun, Wang Yan

Abstract excerpt

Introduction: To identify the clinical phenotype and prognostic determinants in patients with anti-MDA5 antibody-positive dermatomyositis (MDA5+DM) with spontaneous pneumomediastinum (SPM). Methods: We retrospectively analyzed 150 MDA5+DM patients (50 with SPM and 100 without). Clinical, laboratory, and therapeutic profiles were analyzed. Multivariable logistic regression was used to identify factors associated...

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Identifiers

PMID: 42292368
DOI: 10.3389/fimmu.2026.1852637
PMCID: PMC13260135

Genes

CRP
KL

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