Article
Transcription initiation from within P elements generates hypomorphic mutations in Drosophila melanogaster.
Genetics - 1 Jul 2011
LaFave Matthew C, Sekelsky Jeff
Abstract excerpt
Numerous transposable element insertions in Drosophila melanogaster cause hypomorphic mutations. We report that transcription initiation within a region found in many P-element constructs provides an explanation for why some gene function is retained. We detected evidence of this transcription in four different types of P constructs, regardless of whether the insertion was in a coding exon, intron, 5'...
Topics
- 5' Untranslated Regions
- Alleles
- Animals
- Base Sequence
- DNA Transposable Elements
- Drosophila Proteins
- Drosophila melanogaster
- Exons
- Female
- Gene Expression
- Genes, Insect
- Introns