Article
SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2011
Pandey Deepesh, Chen Feng, Patel Anand, Wang Cong-Yi, Dimitropoulou Christiana, Patel Vijay S, Rudic R Daniel, Stepp David W, Fulton David J
Abstract excerpt
OBJECTIVE: Increased protein SUMOylation (small ubiquitin-related modifier [SUMO]) provides protection from cellular stress, including oxidative stress, but the mechanisms involved are incompletely understood. The NADPH oxidases (Nox) are a primary source of reactive oxygen species (ROS) and oxidative stress, and thus our goal was to determine whether SUMO regulates NADPH oxidase activity. METHODS AND RESULTS:...
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