Article
Genome-wide approach to identify novel candidate genes for beta blocker response in heart failure using an experimental model.
Discovery medicine - 1 Apr 2011
Lanfear David E, Yang James J, Mishra Sudhish, Sabbah Hani N
Abstract excerpt
BACKGROUND: We explored use of a canine model of heart failure (HF) for pharmacogenomic discovery, specifically analyzing response to beta blockers (BB). METHODS: Dogs with HF that received BB (n=39) underwent genome-wide genotyping to test the association with changes in left ventricular (LV) volume and ejection fraction after treatment. Resulting candidate genes underwent RNA quantification in cardiac tissue...
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