The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis.

doi:10.1111/j.1365-2265.2011.04030.x

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Article

The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis.

Clinical endocrinology - 1 Aug 2011

Gan Earn H, Mitchell Anna L, Macarthur Katie, Pearce Simon H S

Abstract excerpt

CONTEXT: Genome-wide association studies have discovered various susceptibility alleles that are shared among different autoimmune conditions, implicating several biochemical pathways in the pathogenesis of autoimmunity. A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor, Gly307Ser (rs763361), has recently been identified as conferring risk to many...

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PMID: 21521299
DOI: 10.1111/j.1365-2265.2011.04030.x

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