Article
Phenotypic abnormalities strongly reflect genotype in patients with unexplained cytopenias.
Cytometry. Part B, Clinical cytometry - 1 May 2011
Cutler Jevon A, Wells Denise A, van de Loosdrecht Arjan A, de Baca Monica E, Kalnoski Michael H, Zehentner Barbara K, Eidenschink Lisa, Ghirardelli Keely M, Biggerstaff Julie Sanford, Loken Michael R
Abstract excerpt
BACKGROUND: In patients with unexplained cytopenias, abnormal karyotyping studies can be found with inconclusive light microscopic findings. Multidimensional flow cytometry (FCM) can identify myelomonocytic cells with aberrant phenotypes often not seen by standard morphology. METHODS: In 431 patients presenting with unexplained cytopenia(s) FCM results were compared to abnormal karyotyping and FISH results...
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