Article
[Association of mismatch repair gene polymorphism with susceptibility to sporadic colorectal cancer in Tianjin region].
Yi chuan = Hereditas - 1 Dec 2010
Li Hui-Chen, Feng Hui-Yuan, Zhang Xi-Peng, Liu Rui, Ma Dong-Wang, Qin Hai, Zhou Yi, Yu Lin
Abstract excerpt
To investigate the possible association of mismatch repair gene single nucleotide polymorphisms (SNPs) with susceptibility to sporadic colorectal cancer (SCRC), the genotypes of hMLH1 394G/C, hMSH2 943-1G/A, hMSH2 1917T/G, and hMSH2 2783C/A were detected by PCR-denaturing high-performance liquid chromatography (DHPLC) in 600 SCRC patients and 600 healthy controls. The genotype distribution of hMSH2 2783C/A in...
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