Article
A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.
The Journal of biological chemistry - 24 Dec 2010
Porter Morwenna Y, Xie Keqiang, Pozharski Edwin, Koelle Michael R, Martemyanov Kirill A
Abstract excerpt
Regulators of G protein signaling (RGS) proteins of the R7 subfamily limit signaling by neurotransmitters in the brain and by light in the retina. They form obligate complexes with the Gβ5 protein that are subject to proteolysis to control their abundance and alter signaling. The mechanisms that regulate this proteolysis, however, remain unclear. We used genetic screens to find mutations in Gβ5 that selectively...
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