Article
In vitro investigation of the glutathione transferase M1 and T1 null genotypes as risk factors for troglitazone-induced liver injury.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2011
Usui Toru, Hashizume Takanori, Katsumata Takashi, Yokoi Tsuyoshi, Komuro Setsuko
Abstract excerpt
The double null mutation of glutathione transferase, GSTM1 and GSTT1, is reported to influence troglitazone-associated abnormal increases of alanine aminotransferase and aspartate aminotransferase. However, no nonclinical data with a bearing on the clinical outcomes and underlying mechanisms have hitherto been reported. To investigate whether deficiency in GSTM1 and/or GSTT1 is related to troglitazone...
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