Article
Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2011
Okada Ran, Maeda Kazuya, Nishiyama Takahito, Aoyama Shinsuke, Tozuka Zenzaburo, Hiratsuka Akira, Ikeda Toshihiko, Kusuhara Hiroyuki, Sugiyama Yuichi
Abstract excerpt
Null mutation of glutathione transferase (GST) M1 and GSTT1 was reported to correlate statistically with an abnormal increase in the plasma levels of alanine aminotransferase or aspartate aminotransferase caused by troglitazone in diabetic patients (Clin Pharmacol Ther, 73:435-455, 2003). This clinical evidence leads to the hypothesis that GSH conjugation catalyzed by GSTT1 and GSTM1 has a role in the elimination...
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