Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation

31 Mar 2021

Abstract excerpt

Key Points Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Immunodeficiency and Autoimmune Disorders
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33787858
DOI: 10.1182/bloodadvances.2020003858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulationPMID 33787858Read ↗

The immune system in Down Syndrome: Autoimmunity and severe infections.Semantic proximity Read ↗

Immune Defect in Adults With Down Syndrome: Insights Into a Complex Issue.Semantic proximity Read ↗

Hematological disorders in children with Down syndrome.Semantic proximity Read ↗

Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down SyndromeSemantic proximity Read ↗

Recent advances in the understanding of transient abnormal myelopoiesis in Down syndromeSemantic proximity Read ↗

The natural history of transient abnormal myelopoiesis in neonates and children with Down syndromeSemantic proximity Read ↗

Inborn Errors of Adaptive Immunity in Down SyndromeSemantic proximity Read ↗

Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down SyndromeSemantic proximity Read ↗

Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganizationSemantic proximity Read ↗

Quantitative, Phenotypical, and Functional Characterization of Cellular Immunity in Children and Adolescents With Down Syndrome.Semantic proximity Read ↗

Altered Expression of Immune-Related Genes in Children with Down SyndromeSemantic proximity Read ↗

Transient Abnormal Myelopoiesis and AML in Down Syndrome: an UpdateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.