PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca²⁺/Calmodulin‐Dependent kinase II‐δ activation in mouse models of down syndrome

Abstract excerpt

Pcp4/pep19 is a modulator of Ca(2+) -CaM, a key molecule for calcium signaling, expressed in postmitotic neuroectoderm cells during mouse embryogenesis. The PCP4 gene is located on human chromosome 21 and is present in three copies in Down syndrome (DS). To evaluate the consequences of three copies of this gene on the development of these cells in the nervous system, we constructed a transgenic (TgPCP4) mouse...

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