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Article

Brain ventriculomegaly in Down syndrome mice is caused by Pcp4 dose-dependent cilia dysfunction.

Human molecular genetics - 1 Mar 2017

Raveau Matthieu, Nakahari Takashi, Asada Sachie, Ishihara Keiichi, Amano Kenji, Shimohata Atsushi, Sago Haruhiko, Yamakawa Kazuhiro

Abstract excerpt

Down syndrome is a leading cause of congenital intellectual disability caused by an additional copy of the chromosome 21. Patients display physiological and morphological changes affecting the brain and its function. Previously we showed that Ts1Cje and Ts2Cje, Down syndrome mouse models carrying overlapping trisomic segments of different length, show similar ventriculomegaly and neurogenesis dysfunction leading...

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PMID: 28069794
DOI: 10.1093/hmg/ddx007

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