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Article

Association screening in the Epidermal Differentiation Complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema.

The Journal of investigative dermatology - 1 Aug 2011

Marenholz Ingo, Rivera Vladimir A Gimenez, Esparza-Gordillo Jorge, Bauerfeind Anja, Lee-Kirsch Min-Ae, Ciechanowicz Andrzej, Kurek Michael, Piskackova Tereza, Macek Milan, Lee Young-Ae

Abstract excerpt

The genetically determined impairment of the skin barrier is a primary cause of eczema. As numerous genes essential for an intact epidermis reside within the epidermal differentiation complex (EDC), we screened the National Center for Biotechnology Information (NCBI) database for putatively functional polymorphisms in the EDC genes and tested them for association with eczema. We identified 20 polymorphisms with...

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Source

Identifiers

PMID: 21490620
DOI: 10.1038/jid.2011.90

Genes

SPRR3
FLG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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