Article
Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2011
Dziurzynski Kristine, Wei Jun, Qiao Wei, Hatiboglu Mustafa Aziz, Kong Ling-Yuan, Wu Adam, Wang Yongtao, Cahill Daniel, Levine Nicholas, Prabhu Sujit, Rao Ganesh, Sawaya Raymond, Heimberger Amy B
Abstract excerpt
PURPOSE: Cytomegalovirus (CMV) has been ubiquitously detected within high-grade gliomas, but its role in gliomagenesis has not been fully elicited. EXPERIMENTAL DESIGN: Glioblastoma multiforme (GBM) tumors were analyzed by flow cytometry to determine CMV antigen expression within various glioma-associated immune populations. The glioma cancer stem cell (gCSC) CMV interleukin (IL)-10 production was determined by...
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