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Article

Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization.

Mucosal immunology - 1 Mar 2018

Frederick D R, Goggins J A, Sabbagh L M, Freytag L C, Clements J D, McLachlan J B

Abstract excerpt

Infectious diarrheal diseases are the second leading cause of death in children under 5 years, making vaccines against these diseases a high priority. It is known that certain vaccine adjuvants, chiefly bacterial ADP-ribosylating enterotoxins, can induce mucosal antibodies when delivered parenterally. Based on this, we reasoned vaccine-specific mucosal cellular immunity could be induced via parenteral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28792004
DOI: 10.1038/mi.2017.70
PMCID: PMC6252260

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