Article
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
Diabetes - 1 Mar 2013
Tabassum Rubina, Chauhan Ganesh, Dwivedi Om Prakash, Mahajan Anubha, Jaiswal Alok, Kaur Ismeet, Bandesh Khushdeep, Singh Tejbir, Mathai Benan John, Pandey Yogesh, Chidambaram Manickam, Sharma Amitabh, Chavali Sreenivas, Sengupta Shantanu, Ramakrishnan Lakshmi, Venkatesh Pradeep, Aggarwal Sanjay K, Ghosh Saurabh, Prabhakaran Dorairaj, Srinath Reddy K, Saxena Madhukar, Banerjee Monisha, Mathur Sandeep, Bhansali Anil, Shah Viral N, Madhu Sri Venkata, Marwaha Raman K, Basu Analabha, Scaria Vinod, McCarthy Mark I, Venkatesan Radha, Mohan Viswanathan, Tandon Nikhil, Bharadwaj Dwaipayan
Abstract excerpt
Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored but high-risk group. We identified a new type 2 diabetes-associated locus at 2q21, with the lead signal being rs6723108 (odds ratio 1.31; P = 3.32 × 10⁻⁹). Imputation analysis refined the signal...
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