An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population.

doi:10.1371/journal.pone.0056365

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Article

An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population.

PloS one - 1 Jan 2013

Zhang Yu-Xiang, Liu Yan, Dong Jing, Wang You-Xin, Wang Jing, Zhuang Guo-Qing, Han Shu-Jing, Guo Qing-Qing, Luo Yan-Xia, Zhang Jie, Peng Xiao-Xia, Zhang Ling, Yan Yu-Xiang, Yang Xing-Hua, Wang Hong, Han Xu, Liu Guang-Xu, Kang You-Hou, Liu You-Qin, Weng Sheng-Feng, Zhang Hong, Zhang Xiao-Qiang, Jia Ke-Bao, Wang Li, Zhao Lei, Xiao Zhong-Xin, Zhang Shu-Hua, Wu Hui-Hui, Lai Qing-Xuan, Qi Na, Wang Wei, Gaisano Herbert, Liu Fen, He Yan

Abstract excerpt

Since the KCNB1 encoding Kv2.1 channel accounts for the majority of Kv currents modulating insulin secretion by pancreatic islet beta-cells, we postulated that KCNB1 is a plausible candidate gene for genetic variation contributing to the variable compensatory secretory function of beta-cells in type-2 diabetes (T2D). We conducted two studies, a case-control study and a cross-section study, to investigate the...

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PMID: 23431371
DOI: 10.1371/journal.pone.0056365
PMCID: PMC3576392

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KCNB1

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