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Article

Postnatal dendritic development in lumbar motoneurons in mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis.

Neuroscience - 3 May 2012

Filipchuk A A, Durand J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motoneuron (MN) degeneration and muscle paralysis. Cu/Zn superoxide dismutase (SOD1) mutant mice develop an ALS-like phenotype similar to that seen in human. Recently it has been shown in SOD1 mice that the excitability and morphology of spinal MNs are altered at postnatal age, long before overt clinical symptoms. In the...

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Source

Identifiers

PMID: 22387111
DOI: 10.1016/j.neuroscience.2012.01.046

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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