Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Postnatal dendritic development in lumbar motoneurons in mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis.

Neuroscience - 3 May 2012

Filipchuk A A, Durand J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motoneuron (MN) degeneration and muscle paralysis. Cu/Zn superoxide dismutase (SOD1) mutant mice develop an ALS-like phenotype similar to that seen in human. Recently it has been shown in SOD1 mice that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Dendrites
Share to Lumbar Vertebrae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Motor Neurons

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 22387111
DOI: 10.1016/j.neuroscience.2012.01.046

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22387111-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Postnatal dendritic development in lumbar motoneurons in mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis.PMID 22387111Read ↗

Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor NeuronsSemantic proximity Read ↗

ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor NeuronsSemantic proximity Read ↗

The vulnerability of spinal motoneurons and soma size plasticity in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons.Semantic proximity Read ↗

Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice.Semantic proximity Read ↗

Increase in presynaptic territory of C-terminals on lumbar motoneurons of G93A SOD1 mice during disease progression.Semantic proximity Read ↗

Human superoxide dismutase 1 overexpression in motor neurons of Caenorhabditis elegans causes axon guidance defect and neurodegeneration.Semantic proximity Read ↗

Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene.Semantic proximity Read ↗

Altered sensorimotor development in a transgenic mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1(G93A) mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.