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Article

PARP inhibitors in oncology: a new synthetic lethal approach to cancer therapy.

24 May 2011

Abstract excerpt

Damage to DNA has emerged as a major culprit in cancer. Mammalian cells are continuously exposed to DNA damage, caused by exogenous toxins as well as endogenous activities such as DNA replication and cellular free radical generation. It is therefore essential that cells have DNA repair mechanisms in place to preserve its genomic integrity. Interestingly, cancer cells frequently harbour defects in DNA repair...

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PMID: 21485757
DOI: 10.2143/acb.66.1.2062507

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