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Article

Inhibition of poly(ADP-ribosyl)ation in cancer: Old and new paradigms revisited

12 Jul 2014

Abstract excerpt

Inhibitors of poly(ADP-ribose) polymerases actualized the biological concept of synthetic lethality in the clinical practice, yielding a paradigmatic example of translational medicine. The profound sensitivity of tumors with germline BRCA mutations to PARP1/2 blockade owes to inherent defects of the BRCA-dependent homologous recombination machinery, which are unleashed by interruption of PARP DNA repair activity...

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PMID: 25026313
DOI: 10.1016/j.bbcan.2014.07.004

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