Article
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.
PloS one - 4 Apr 2011
Savas Sevtap, Azorsa David O, Jarjanazi Hamdi, Ibrahim-Zada Irada, Gonzales Irma M, Arora Shilpi, Henderson Meredith C, Choi Yun Hee, Briollais Laurent, Ozcelik Hilmi, Tuzmen Sukru
Abstract excerpt
Simvastatin and lovastatin are statins traditionally used for lowering serum cholesterol levels. However, there exists evidence indicating their potential chemotherapeutic characteristics in cancer. In this study, we used bioinformatic analysis of publicly available data in order to systematically identify the genes involved in resistance to cytotoxic effects of these two drugs in the NCI60 cell line panel. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.