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Endothelial cell activation by antiphospholipid antibodies is modulated by Krüppel-like transcription factors

12 Apr 2011

Abstract excerpt

Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority of APLAs are directed against phospholipid-binding proteins, particularly β₂-glycoprotein I (β₂GPI). Anti-β₂GPI antibodies activate endothelial cells in a β₂GPI-dependent manner through a pathway that involves NF-κB. Krüppel-like factors (KLFs) play a...

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PMID: 21482710
DOI: 10.1182/blood-2010-10-313072

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