Article
LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer.
Cancer research - 1 Jun 2011
Permuth-Wey Jennifer, Kim Donghwa, Tsai Ya-Yu, Lin Hui-Yi, Chen Y Ann, Barnholtz-Sloan Jill, Birrer Michael J, Bloom Gregory, Chanock Stephen J, Chen Zhihua, Cramer Daniel W, Cunningham Julie M, Dagne Getachew, Ebbert-Syfrett Judith, Fenstermacher David, Fridley Brooke L, Garcia-Closas Montserrat, Gayther Simon A, Ge William, Gentry-Maharaj Aleksandra, Gonzalez-Bosquet Jesus, Goode Ellen L, Iversen Edwin, Jim Heather, Kong William, McLaughlin John, Menon Usha, Monteiro Alvaro N A, Narod Steven A, Pharoah Paul D P, Phelan Catherine M, Qu Xiaotao, Ramus Susan J, Risch Harvey, Schildkraut Joellen M, Song Honglin, Stockwell Heather, Sutphen Rebecca, Terry Kathryn L, Tyrer Jonathan, Vierkant Robert A, Wentzensen Nicolas, Lancaster Johnathan M, Cheng Jin Q, Sellers Thomas A
Abstract excerpt
Defective microRNA (miRNA) biogenesis contributes to the development and progression of epithelial ovarian cancer (EOC). In this study, we examined the hypothesis that single nucleotide polymorphisms (SNP) in miRNA biogenesis genes may influence EOC risk. In an initial investigation, 318 SNPs in 18 genes were evaluated among 1,815 EOC cases and 1,900 controls, followed up by a replicative joint meta-analysis of...
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