Article
Optimal mutation sites for PRE data collection and membrane protein structure prediction.
Structure (London, England : 1993) - 13 Apr 2011
Chen Huiling, Ji Fei, Olman Victor, Mobley Charles K, Liu Yizhou, Zhou Yunpeng, Bushweller John H, Prestegard James H, Xu Ying
Abstract excerpt
Nuclear magnetic resonance paramagnetic relaxation enhancement (PRE) measures long-range distances to isotopically labeled residues, providing useful constraints for protein structure prediction. The method usually requires labor-intensive conjugation of nitroxide labels to multiple locations on the protein, one at a time. Here a computational procedure, based on protein sequence and simple secondary structure...
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