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Article

Therapy for hyperthermia-induced seizures in Scn1a mutant rats.

Epilepsia - 1 May 2011

Hayashi Keiichiro, Ueshima Satoshi, Ouchida Mamoru, Mashimo Tomoji, Nishiki Teiichi, Sendo Toshiaki, Serikawa Tadao, Matsui Hideki, Ohmori Iori

Abstract excerpt

PURPOSE: Mutations in the SCN1A gene, which encodes the α1 subunit of voltage-gated sodium channels, cause generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI). N1417H-Scn1a mutant rats are considered to be an animal model of human FS+ or GEFS+. To assess the pharmacologic validity of this model, we compared the efficacies of eight different antiepileptic drugs...

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Identifiers

PMID: 21480876
DOI: 10.1111/j.1528-1167.2011.03046.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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