Article
A Bayesian approach to the probability of coronary heart disease subject to the -308 tumor necrosis factor-α SNP.
Bio Systems - 1 Sept 2011
Vourvouhaki Ekaterini, Carvalho C Sofia
Abstract excerpt
We study the correlation of the occurrence of coronary heart disease (CHD) with the presence of the single-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosis factor alpha (TNF-α) gene. We also consider the influence of the occurrence of type 2 diabetes (t2DM). Using Bayesian inference, we first pursue a bottom-up approach to compute the working hypothesis and the probabilities derivable from...
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