Article
Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.
BMC medicine - 7 Mar 2017
Lin Xinyi, Lim Ives Yubin, Wu Yonghui, Teh Ai Ling, Chen Li, Aris Izzuddin M, Soh Shu E, Tint Mya Thway, MacIsaac Julia L, Morin Alexander M, Yap Fabian, Tan Kok Hian, Saw Seang Mei, Kobor Michael S, Meaney Michael J, Godfrey Keith M, Chong Yap Seng, Holbrook Joanna D, Lee Yung Seng, Gluckman Peter D, Karnani Neerja
Abstract excerpt
BACKGROUND: Obesity is an escalating health problem worldwide, and hence the causes underlying its development are of primary importance to public health. There is growing evidence that suboptimal intrauterine environment can perturb the metabolic programing of the growing fetus, thereby increasing the risk of developing obesity in later life. However, the link between early exposures in the womb, genetic...
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