Article
c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.
American journal of respiratory and critical care medicine - 15 Jun 2011
Lindsey James Y, Ganguly Koustav, Brass David M, Li Zhuowei, Potts Erin N, Degan Simone, Chen Huaiyong, Brockway Brian, Abraham Soman N, Berndt Annerose, Stripp Barry R, Foster W Michael, Leikauf George D, Schulz Holger, Hollingsworth John W
Abstract excerpt
RATIONALE: Previously, we demonstrated a candidate region for susceptibility to airspace enlargement on mouse chromosome 5. However, the specific candidate genes within this region accounting for emphysema-like changes remain unrecognized. c-Kit is a receptor tyrosine kinase within this candidate gene region that has previously been recognized to contribute to the survival, proliferation, and differentiation of...
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