Article
Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer.
Journal of cancer research and clinical oncology - 1 Jul 2011
Schimanski Carl C, Moehler Markus, Gockel Ines, Zimmermann Tim, Lang Hauke, Galle Peter R, Berger Martin R
Abstract excerpt
BACKGROUND: Molecular metastases are precursors of postoperative recurrence, detected by molecular-biological tools. Chemokines and their receptors contribute to dissemination and local immune recognition. A strong expression of the chemokine receptor CCR5 is associated with non-metastatic colorectal cancer and increased CD8+ T-cell infiltration. The aim of this study was to analyze whether CCR5 expression...
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