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Article

RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation.

The EMBO journal - 18 May 2011

Rösel Tanja Dorothe, Hung Lee-Hsueh, Medenbach Jan, Donde Katrin, Starke Stefan, Benes Vladimir, Rätsch Gunnar, Bindereif Albrecht

Abstract excerpt

Precise 5' splice-site recognition is essential for both constitutive and regulated pre-mRNA splicing. The U1 small nuclear ribonucleoprotein particle (snRNP)-specific protein U1C is involved in this first step of spliceosome assembly and important for stabilizing early splicing complexes. We used an embryonically lethal U1C mutant zebrafish, hi1371, to investigate the potential genomewide role of U1C for...

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Identifiers

PMID: 21468032
DOI: 10.1038/emboj.2011.106
PMCID: PMC3098479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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