Article
Steroidogenesis and steroidogenic gene expression in postnatal fetal rat Leydig cells.
Molecular and cellular endocrinology - 20 Jul 2011
Weisser Judith, Landreh Luise, Söder Olle, Svechnikov Konstantin
Abstract excerpt
We studied steroidogenesis and the regulation of Leydig cell-specific gene expression in primary cultures of highly purified postnatal fetal Leydig cells (PFLCs). PFLCs activated by hCG and (Bu)(2)cAMP demonstrated transient capacity to produce testosterone (T) in vitro. A time dependent decline in T production by (Bu)(2)cAMP-stimulated PFLCs was observed and associated with the accumulation of progesterone in...
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