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Article

Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo

20 Oct 2022

Abstract excerpt

BACKGROUND: Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats demonstrating that normal male development and adult reproductive function depend on sufficient androgen exposure during a sensitive fetal period, called the masculinization...

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PMID: 36266662
DOI: 10.1186/s12916-022-02602-y

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