Article
A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival.
BMC cancer - 1 Apr 2011
Batra Jyotsna, Nagle Christina M, O'Mara Tracy, Higgins Melanie, Dong Ying, Tan Olivia L, Lose Felicity, Skeie Lene Marie, Srinivasan Srilakshmi, Bolton Kelly L, Song Honglin, Ramus Susan J, Gayther Simon A, Pharoah Paul D P, Kedda Mary-Anne, Spurdle Amanda B, Clements Judith A
Abstract excerpt
BACKGROUND: KLK15 over-expression is reported to be a significant predictor of reduced progression-free survival and overall survival in ovarian cancer. Our aim was to analyse the KLK15 gene for putative functional single nucleotide polymorphisms (SNPs) and assess the association of these and KLK15 HapMap tag SNPs with ovarian cancer survival. RESULTS: In silico analysis was performed to identify KLK15 regulatory...
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