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Article

PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a Gα‐protein leads to biased signaling

21 Dec 2018

Abstract excerpt

ABSTRACT Idiopathic hypogonadotropic hypogonadism (IHH) is a rare disorder caused by the deficient production, secretion, or action of gonadotropin‐releasing hormone. Prokineticin (PROK) receptor 2 ( PROKR2 ), a causative gene for IHH, encodes a GPCR PROKR2. When PROKR2 binds to its ligands PROKs, it may activate several signaling pathways, including IP3/Ca 2+ , MAPK, and cAMP pathways. However, the mutational...

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PMID: 30576231
DOI: 10.1096/fj.201801575r

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