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Article

Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.

Arthritis and rheumatism - 1 Apr 2011

Freudenberg Jan, Lee Hye-Soon, Han Bok-Ghee, Shin Hyoung Do, Kang Young Mo, Sung Yoon-Kyoung, Shim Seung-Cheol, Choi Chan-Bum, Lee Annette T, Gregersen Peter K, Bae Sang-Cheol

Abstract excerpt

OBJECTIVE: To perform a genome-wide association study (GWAS) in Koreans in order to identify susceptibility loci for rheumatoid arthritis (RA). METHODS: We generated high-quality genotypes for 441,398 single-nucleotide polymorphisms (SNPs) in 801 RA cases and 757 controls. We then tested 79 markers from 46 loci for replication in an independent sample of 718 RA cases and 719 controls. RESULTS: Genome-wide...

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Source

Identifiers

PMID: 21452313
DOI: 10.1002/art.30235

Genes

AFF3
ARHGEF3
BLK
CCL21
FLI1
LCP2
PADI4
PTPN2
STAT4
TRHDE

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