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Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers.

Cancer medicine - 1 Feb 2024

Mulugeta Anwar, Lumsden Amanda L, Madakkatel Iqbal, Stacey David, Lee S Hong, Mäenpää Johanna, Oehler Martin K, Hyppönen Elina

Abstract excerpt

BACKGROUND: Ovarian cancer (OC) is commonly diagnosed among older women who have comorbidities. This hypothesis-free phenome-wide association study (PheWAS) aimed to identify comorbidities associated with OC, as well as traits that share a genetic architecture with OC. METHODS: We used data from 181,203 white British female UK Biobank participants and analysed OC and OC subtype-specific genetic risk scores...

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PMID: 38457211
DOI: 10.1002/cam4.7051
PMCID: PMC10923028

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