Article
Environmentally induced differential amplification of mitochondrial populations.
The Biochemical journal - 1 Sept 1990
Tonsgard J H, Tung B, Kornafel K S, Getz G S
Abstract excerpt
Resistance to the drug rutamycin, an inhibitor of mitochondrial ATPase, has been shown to be cytoplasmically inherited in a mouse fibroblast line (TL) on fusion of the cytoplast (enTL) with a nucleated recipient A9 [Lichtor & Getz (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 324-328]. The cytoplasmic hybrid (cybrid) so formed may be readily grown in the presence [CY(+)] or absence [CY(-)] of rutamycin. The ATPase of...
Topics
- Adenosine Triphosphatases
- Animals
- Cell Division
- Cell Line
- DNA, Mitochondrial
- Drug Resistance
- Hybrid Cells
- Hydrogen-Ion Concentration
- L Cells
- Mice
- Mitochondria
- Mutation