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Article

Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms.

Oncogene - 18 Aug 2011

Bug M, Dobbelstein M

Abstract excerpt

Mutant p53 frequently accumulates in cancer cells and promotes tumor cell invasion, as part of its gain of function. Its accumulation is partially due to enhanced stability, but little is known about how the mRNA levels of mutant p53 can be regulated. Likewise, the impact of cancer therapy on the levels of mutant p53 is poorly understood. We show here that the anthracyclines doxorubicin, daunorubicin and...

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Identifiers

PMID: 21441950
DOI: 10.1038/onc.2011.72

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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