Article
Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose.
Nature communications - 27 Jan 2023
Qiao Zhen, Sidorenko Julia, Revez Joana A, Xue Angli, Lu Xueling, Pärna Katri, Snieder Harold, Visscher Peter M, Wray Naomi R, Yengo Loic
Abstract excerpt
The genetic regulation of post-prandial glucose levels is poorly understood. Here, we characterise the genetic architecture of blood glucose variably measured within 0 and 24 h of fasting in 368,000 European ancestry participants of the UK Biobank. We found a near-linear increase in the heritability of non-fasting glucose levels over time, which plateaus to its fasting state value after 5 h post meal (h2 = 11%;...
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