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Article

Blockade of T-Type Ca<sup>2+</sup>Channels Inhibits Human Ovarian Cancer Cell Proliferation

26 Mar 2011

Abstract excerpt

Regulation of Ca(2+) channels has been implicated in the progression of tumor cells. We report here that T-type Ca(2+) channel expression in human ovarian cancer tissues is greatly increased compared to normal ovarian tissues. Blockade of T-type Ca(2+) channel with NNC 55-0396, mibefradil, or by specifically knocking down the expression of these proteins with siRNA-Ca(v)3.1/3.2 suppressed the proliferation of two...

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PMID: 21438841
DOI: 10.3109/07357907.2011.568565

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