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Article

Development of transgenic mice expressing a conditionally active form of the eIF2α kinase PKR.

Genesis (New York, N.Y. : 2000) - 1 Sept 2011

Papadakis Andreas I, Baltzis Dionissios, Buensuceso Ryan C, Peidis Philippos, Koromilas Antonis E

Abstract excerpt

Phosphorylation of the alpha (α) subunit of the eukaryotic initiation factor 2 (eIF2) at serine 51 is an important mechanism of translational control in response to various forms of environmental stress. In metazoans, eIF2α phosphorylation is mediated by four kinases each of which becomes activated by distinct stimuli. Previous work established that expression of a chimera protein comprising of the bacteria...

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PMID: 21438126
DOI: 10.1002/dvg.20749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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