Article
Gene copy number reduction in the azoospermia factor c (AZFc) region and its effect on total motile sperm count.
Human molecular genetics - 15 Jun 2011
Noordam Michiel J, Westerveld G Henrike, Hovingh Suzanne E, van Daalen Saskia K M, Korver Cindy M, van der Veen Fulco, van Pelt Ans M M, Repping Sjoerd
Abstract excerpt
The azoospermia factor c (AZFc) region harbors multi-copy genes that are expressed in the testis. Deletions of the AZFc region lead to reduced copy numbers of these genes. Four (partial) AZFc deletions have been described of which the b2/b4 and gr/gr deletions affect semen quality. In most studies, (partial) AZFc deletions are identified and characterized using plus/minus sequence site tag (STS) polymerase chain...
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